Hamilton County, whose county seat is Cincinnati, Ohio, continues to witness high rates of overdoses, both fatal and nonfatal. Since 2019, the number of fatal overdoses has increased from 349 deaths to 388 deaths in 2021. A 2022 regional survey of 7th- through 12th-grade students from 60 schools found that 18 percent of students believe that prescription drugs were fairly easy/very easy to get and that the average age of first use of prescription drugs was 11.9 years.

Hamilton County Public Health (HCPH) partnered with the Colerain Police Department in focusing on Colerain Township, Ohio, which has one drop box location within the township limits. The township is the second-largest municipality in Ohio. HCPH used Comprehensive Secure and Responsible Drug Disposal Program funds to purchase 18,000 drug disposal pouches and 3,500 Rx Destroyer™ disposal units to allow for at-home disposal of medications. Disposal options were made available to anyone in the county. Drug take-back opportunities were expanded to include community events, the quick response team, police all-terrain vehicles, and emergency medical services vehicles.